Tea Catechin Inhibits Biofilm Formation of Methicillin-Resistant S. aureus

Staphylococcus aureus (S. aureus) is the most common pathogen causing infections from skin to systemic infections. The success of S. can partially be attributed its antibiotic resistance and ability form biofilm. An increasing prevalence methicillin-resistant (MRSA) becomes a global public health problem in recent decades. Here, effects tea catechin extracts on growth biofilm formation three MRSA strains were investigated. results revealed that potently suppressed growth, minimal inhibitory concentration against these was 0.1 g/L. Then, inhibited dose-dependent manner measured with colorimetric method, effect also demonstrated by scanning electron microscopy assay. Moreover, adhesin genes biofilm-associated protein (bap), bone sialoprotein-binding (bbp), collagen-binding (cna), clumping factors A (clfA), fibronectin binding B (fnbA fnbB), intercellular adhesion gene BC (icaBC) scanned, shown fnbA icaBC present strains. Furthermore, depressed expression Therefore, inhibition probably associated downregulation